Age is a determinant factor for measures of concentration and effect in children requiring unfractionated heparin

F Newall; V Ignjatovic; L Johnston; R Summerhayes; G Lane; N Cranswick; P Monagle

Journal article

Age is a determinant factor for measures of concentration and effect in children requiring unfractionated heparin

F Newall, V Ignjatovic, L Johnston, R Summerhayes, G Lane, N Cranswick, P Monagle

Thrombosis and Haemostasis | Published : 2010

DOI: 10.1160/TH09-09-0624

Abstract

Previous studies investigating continuous unfractionated heparin (UFH) therapy report age-related differences in UFH response in children, as measured by APTT and anti-Xa assay. This study determined the age-related response following administration of a single UFH bolus of 75-100 IU/kg in children. Venous blood samples were collected from children (n=56) at 15, 30, 45 and 120 minutes post-UFH. Anti-Xa, anti-IIa, APTT, TCT and protamine titration were performed on all samples. Age-dependent differences in the effect and concentration of UFH were identified for the anti-Xa, anti-IIa and protamine titration assays, respectively. In addition, a trend suggesting a proportional increase in anti-X..

View full abstract

University of Melbourne Researchers

Fiona Newall Author

Vera Ignjatovic Author

Paul Monagle Author

Related Projects (1)

Age-related response to heparin in children.

Unfractionated Heparin (UFH) is the most commonly used anticoagulant (blood thinning drug) in children. Despite this, the clinical evidence,..

Grants

Awarded by NHMRC

Funding Acknowledgements

This project was supported by an NHMRC Research Grant #454385. Dr Ignjatovic is supported by the Sanofi-Aventis Clinical Research Fellowship. Fiona Newall held an Australian Postgraduate Award.